Sudhakar Beeravelli, Vyasamurthy Akondi and Madhavi Nimmathota*
Aim: Aim of the present study is to develop and characterize simvastatin niosomal film for effective buccal delivery.
Methods: Simvastatin niosomes were developed by film hydration technique followed by high-pressure homogenization using chiller at 5°C. The simvastatin niosomes were characterized for various physicochemical parameters and simvastatin plain and niosomal films were prepared using PEO as the base by solvent casting technique.
Results: From the simvastatin niosomes suspension, the percentage assay was found in the range of 96 to 103%, particles size was found in the range of 112nm to 308nm, the zeta potential was found in the range of -9 to -25.8mV, the %EE was found in the range of 28% to 91% and the in vitro permeation was found in the range of 43.41% to 98% respectively. The niosomal film shown superior results as compared to simvastatin plain film. The FTIR and DSC confirm the compatibility among the existed excipients.
Conclusion: Niosomes alter the physicochemical properties of simvastatin by buccal route. The prolonged permeation (96.12% up to 24hrs) of simvastatin was observed from niosomes film across the porcine buccal cavity, due to the presence of CPE in the composition, which would be useful for effective buccal delivery.
Niosomes, Span 60, Cholesterol, Permeation, buccal films, and Chemical permeation enhancer.
Airis PHARMA PVT LTD, ALEAP Industrial Area, Gajularamaram, Hyderabad, Telangana, Department of Pharmacy & Pharmacology, School of medicine, University of Tasmania, Hobart, Department of Pharmaceutics, CMR College of Pharmacy, Hyderabad, Telangana