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Formulation and Characterization of Febuxostat loaded Nanostructured Lipid Carriers (NLCs) - Gel for Topical Treatment of Gout

Author(s):

Navni Sharma, Sandeep Kumar, Garima Joshi* and Deepak Choudhary *  

Abstract:


Background: The aim of present study was to formulate and characterize Nano Structured lipid carriers (NLCs) of Febuxostat (FB) incorporated in gel for the treatment of Gout. FB is a Xanthine Oxidase (XO) inhibitor drug used for chronic Gout and hyperuricemia. FB is BCS class II drug so water solubility is very poor and due to its poor solubility and wettability, it leads to poor dissolution. The hot high pressure homogenization technique was used in this study to improve physicochemical property of FB.

Method: The carbopol 934 was used to prepare NLCs Gel of FB. The NLCs of FB was prepared in different drug: polymer ratios w/w (2:1), (1:1), (1:2), (1:3) and (1:4) with solid lipid (Stearic Acid) and liquid lipid (Oleic acid). The preformulation study of FB included FTIR study melting point, standard calibration curves and drug polymer interaction study.

Result: The NLCs (1:3) showed high entrapment and drug content. The NLCs gel formulation had 87% release within 6 hours in controlled manner.

Conclusion: NLCs gel modifies the drug release, increases the bioavailability and reduces side effects of FB. The prepared gel is the efficient formulation for the better treatment of chronic Gout and hyperuricemia. The research findings have shown the undesirable side effects associated with the oral route can be reduced by use of NLCs formulation through transdermal route in an effective manner.

Keywords:

Febuxostat, NLCs, Carbopol Gel, Gout.

Affiliation:

Department of Pharmacy, UIPS, Gharuan, Mohali, Punjab, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan



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