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Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters

Author(s):

Harpreet Kaur Khanuja, Rajendra Awasthi, Meenu Mehta, Saurabh Satija, Alaa AA Aljabali, Murtaza M. Tambuwala, Dinesh Kumar Chellappan, Kamal Dua and Harish Dureja*   Pages 1 - 16 ( 16 )

Abstract:


Background: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.

Methods: Extensive information related to nanosuspensions and its associated patents were collected using PubMed and Google Scholar.

Results: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are costeffective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.

Conclusion: Nanosuspensions plays a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, occular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.

Keywords:

Nanosuspension, colloidal, stability, spin coating, high-pressure homogenization, dissolution rate

Affiliation:

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, Uttar Pradesh, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, New South Wales, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, Faculty of Pharmacy, Department of Pharmaceutical Sciences, Yarmouk University, Irbid, School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, New South Wales, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak



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